Chemical constituents and acetylcholinesterase inhibitory activity of Piper abbreviatum Opiz

Plants of the genus Piper have long been used as medicinal herbs. The chemistry species has widely investigated and phytochemical investigations conducted in all parts world led to isolation a number physiologically active compounds. Thus, this study was carried out investigate phytochemicals from abbreviatum their acetylcholinesterase inhibitory activity, which not previously investigated. Fractionation purification aerial P. identification five methoxylated flavonoids, namely 5,7-dimethoxyflavone, 4ʹ,5,7-trimethoxyflavone, 3',4',5,7-tetramethoxyflavone, 5-hydroxy-7-methoxyflavone, 5-hydroxy-4ʹ,7-dimethoxyflavone, together with lupeol, lupenone, β-sitosterol, β-sitostenone. structures these compounds were obtained by analysis spectroscopic data, well comparison that reported data. Acetylcholinesterase activity revealed isolated flavones found inhibit AChE percentage inhibition values ranged 24.2 58.2%. This is first report on flavonoid abbreviatum. high variants may be chemotaxonomic markers for species.
 
 KEY WORDS: Piperaceae, Piper, abbreviatum, Flavonoid, Acetylcholinesterase
 Bull. Chem. Soc. Ethiop. 2020, 34(3), 625-632.
 DOI: https://dx.doi.org/10.4314/bcse.v34i3.17